There's a lot of talk about use of key-value databases like CouchDB, Tokyo Cabinet, Redis, SimpleDB, etc plus similar ideas like Hypertable. Would be great to hear from people using these, comparing them, advantages/disadvantages, and so on.

More and more startups are getting going with distributed teams, using tools like Campfire, Skype, and IM to facilitate communication. It would be interesting to hear good/bad stories and discuss how to make it work, especially trying to use Agile processes when all the stakeholders aren't in the same room.

Ok...you've got traffic (or you are on your way!) What is the most lucrative way to monetize it? CPA? OfferPal? CPM? AdSense? How do they all compare and which is best? Which of these will be around in 5-10 years and which are just fads?

Strategies and techniques for preventing abusive users from degrading your website's user experience.

iPhone, Andriod, Symbian, Windows Mobile. What works, what doesn't. What's relevant in mobile development in '09

The battle between designers and developers can be resolved with both sides coming out a winner. With the Flash component kit for Flex, it's possible to have your designers build your components visually in Flash, and use them in your Flex applications.

Rails, CakePHP, Django, Jruby on Rails, etc etc. How these frameworks compare, head to head, cage match style.

When does it make sense financially to move from hosted to owned equipment and what are the challenges and benefits

What are the latest UX advances and developmental frameworks being innovated in the last year and the next around online video, video advertising, video in widgets, mobile video, etc.